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KMID : 0882420150880030288
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Korean Journal of Medicine
2015 Volume.88 No. 3 p.288 ~ p.292
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Sudden Deafness in a Patient with Chronic Hepatitis C Treated with Peginterferon and Ribavirin Combination Therapy
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Park Kun-Woo
Park Hyoung-Yoel
Jo Jun-Ho
Jung Min-Woong
Oh Song-Hee
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Abstract
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Combined peginterferon and ribavirin therapy for chronic hepatitis C is associated with several adverse side effects, but sudden deafness is uncommon. Here we report the case of a 62-year-old female with chronic hepatitis C (genotype 1b) who developed sud-den deafness after completing 12 months of treatment with peginterferon α2a (180 μg/week) and ribavirin (1,000 mg/day). Pure-tone audiometry revealed a right-sided sensorineural hearing loss, which did not respond to 2 weeks of systemic corticosteroid therapy. Six months after the end of treatment for chronic hepatitis C, her qualitatively determined hepatitis C virus RNA level was 121,000 IU/mL. Following therapeutic failure, the patient was observed without retreatment for chronic hepatitis C or her hearing loss for a period of 12 months, during which time her hearing recovered almost completely.
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KEYWORD
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Hepatitis C, Chronic, Peginterferon alfa-2a, Ribavirin, Hearing loss, Sudden
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